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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620916
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3caincreases expressionISOPIK3CA (Homo sapiens)6480464CTDCannabidiol results in increased expression of PIK3CA mRNAPMID:27932991 PMID:28025562 PMID:31801206
Pik3camultiple interactionsISOPIK3CA (Homo sapiens)6480464CTD[Cannabidiol co-treated with moringin] results in decreased expression of PIK3CA mRNAPMID:30096889
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