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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620916
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Acc ID: CHEBI:3440
Term: carvacrol
Definition: A phenol that is a natural monoterpene derivative of cymene. An inhibitor of bacterial growth, it is used as a food additive. Potent activator of the human ion channels transient receptor potential V3 (TRPV3) and A1 (TRPA1).
Chemical ID: MESH:C073316
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3caincreases phosphorylationISOPIK3CA (Homo sapiens)6480464CTDcarvacrol results in increased phosphorylation of PIK3CA proteinPMID:32535744
Pik3camultiple interactionsISOPIK3CA (Homo sapiens)6480464CTDErlotinib Hydrochloride inhibits the reaction [carvacrol results in increased phosphorylation of PIK3CA protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of PIK3CA protein]PMID:32535744
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