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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620899
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pik3c3
Name: phosphatidylinositol 3-kinase, catalytic subunit type 3
Acc ID: CHEBI:38635
Term: 3-methyladenine
Definition: A methyladenine that is adenine substituted with a methyl group at position N-3.
Chemical ID: MESH:C025946
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3c3multiple interactionsEXP 6480464CTD3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of PIK3C3 protein]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of PIK3C3 protein]PMID:35066094
Pik3c3multiple interactionsISOPIK3C3 (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]; 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein]]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; 3-methyladenine inhibits the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; 3-methyladenine inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein]; 3-methyladenine inhibits the reaction [Silicon Dioxide promotes the reaction [PIK3C3 protein binds to BECN1 protein]]; [3-methyladenine results in decreased activity of PIK3C3 protein] which results in decreased susceptibility to Hydrogen PeroxidePMID:20525898 PMID:21742779 PMID:25622137 PMID:32061152
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