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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:6541
Term: losartan
Definition: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Chemical ID: MESH:D019808
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2decreases expressionEXP 6480464CTDLosartan results in decreased expression of PTGS2 mRNA; Losartan results in decreased expression of PTGS2 proteinPMID:17244722 PMID:21377515
Ptgs2multiple interactionsEXP 6480464CTDLosartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 mRNA]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 protein]PMID:17244722 PMID:18267125
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTDLosartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]PMID:28578904
Ptgs2multiple interactionsISOPtgs2 (Mus musculus)6480464CTDLosartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]PMID:28578904
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