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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:567361
Term: cladribine
Definition: 2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia.
Chemical ID: MESH:D017338
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDCladribine results in increased activity of CASP9 proteinPMID:11672427 PMID:12948851
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTDBCL2 affects the reaction [Cladribine results in increased cleavage of and results in increased activity of CASP9 protein]; Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP9 protein]; Cladribine results in increased cleavage of and results in increased activity of CASP9 proteinPMID:12948851 PMID:15516989
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