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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases cleavageEXP 6480464CTDDexamethasone results in increased cleavage of CASP9 proteinPMID:30506661
Casp9multiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [TGFB1 protein results in increased activity of CASP9 protein]; fludarabine inhibits the reaction [Dexamethasone results in increased cleavage of CASP9 protein]PMID:15388240 PMID:30506661
Casp9decreases expressionISOCasp9 (Mus musculus)6480464CTDDexamethasone results in decreased expression of CASP9 mRNAPMID:15944155
Casp9increases activityISOCasp9 (Mus musculus)6480464CTDDexamethasone results in increased activity of CASP9 proteinPMID:11399061
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDDexamethasone results in increased activity of CASP9 proteinPMID:11734450 PMID:15574755 PMID:15576458
Casp9increases cleavageISOCASP9 (Homo sapiens)6480464CTDDexamethasone results in increased cleavage of CASP9 proteinPMID:16445836
Casp9multiple interactionsISOCasp9 (Mus musculus)6480464CTDSpermine inhibits the reaction [Dexamethasone results in increased activity of CASP9 protein]PMID:11399061
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTDisocoumarin NM-3 promotes the reaction [Dexamethasone results in increased activity of CASP9 protein]PMID:15574755
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