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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases activityEXP 6480464CTDArsenic Trioxide results in increased activity of CASP9 proteinPMID:21145380
Casp9increases cleavageEXP 6480464CTDArsenic Trioxide results in increased cleavage of CASP9 proteinPMID:24634002
Casp9increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of CASP9 mRNAPMID:19730151
Casp9multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [CASP9 protein binds to CYCS protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased cleavage of CASP9 protein]; Arsenic Trioxide promotes the reaction [CYCS protein binds to CASP9 protein]PMID:21145380 PMID:24634002
Casp9decreases expressionISOCasp9 (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of CASP9 proteinPMID:18336854
Casp9decreases expressionISOCASP9 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of CASP9 proteinPMID:22963400 PMID:29164574
Casp9increases activityISOCasp9 (Mus musculus)6480464CTDArsenic Trioxide results in increased activity of CASP9 proteinPMID:21565247 PMID:24157283
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDArsenic Trioxide results in increased activity of CASP9 proteinPMID:12148893 PMID:12492118 PMID:12883267 PMID:12975549 PMID:15493360 PMID:16010437 PMID:16646077 PMID:17673311 PMID:19771260 PMID:20138156 PMID:20219070 PMID:20534739 PMID:20953137 PMID:21061466 PMID:21418039 PMID:22496356 PMID:23239002 PMID:23737871 PMID:25416439
Casp9increases cleavageISOCasp9 (Mus musculus)6480464CTDArsenic Trioxide results in increased cleavage of CASP9 proteinPMID:24801902
Casp9increases cleavageISOCASP9 (Homo sapiens)6480464CTDArsenic Trioxide results in increased cleavage of CASP9 proteinPMID:12480548 PMID:18387645 PMID:18491231 PMID:19371599 PMID:19468689 PMID:20408844 PMID:20657188 PMID:20723298 PMID:21655183 PMID:25174355 PMID:26160715 PMID:29266867 PMID:32305283
Casp9increases expressionISOCasp9 (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of CASP9 protein modified formPMID:28587418
Casp9increases expressionISOCASP9 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of CASP9 proteinPMID:23980369
Casp9multiple interactionsISOCasp9 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]; Arsenic Trioxide affects the reaction [lipopolysaccharide, E coli O55-B5 affects the cleavage of CASP9 protein]; Arsenic Trioxide promotes the reaction [Drugs, Chinese Herbal results in increased expression of CASP9 protein modified form]; Arsenic Trioxide results in increased cleavage of and results in increased activity of CASP9 protein; Drugs, Chinese Herbal promotes the reaction [Arsenic Trioxide results in increased expression of CASP9 protein modified form]PMID:15688020 PMID:18336854 PMID:24157283 PMID:28587418 PMID:33462182
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTD17-(dimethylaminoethylamino)-17-demethoxygeldanamycin promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP9 protein]; 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein]; [Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein; [Arsenic Trioxide co-treated with Plant Extracts] results in increased cleavage of CASP9 protein; [Bortezomib co-treated with Arsenic Trioxide] results in increased activity of CASP9 protein; [Bortezomib co-treated with Arsenic Trioxide] results in increased expression of CASP9 protein; [Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP9 protein; [Dasatinib co-treated with Arsenic Trioxide] results in increased cleavage of CASP9 protein; [Sulindac co-treated with Arsenic Trioxide] results in increased activity of CASP9 protein; [Valproic Acid co-treated with Arsenic Trioxide] results in increased expression of CASP9 mRNA; [Valproic Acid co-treated with Arsenic Trioxide] results in increased expression of CASP9 protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Poly I-C results in increased activity of CASP9 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Poly I-C promotes the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]]; AKT1 mutant form promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP9 protein]; ARL6IP5 protein promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP9 protein]; Arsenic Trioxide analog results in increased cleavage of and results in increased activity of CASP9 protein; Arsenic Trioxide promotes the reaction [Dasatinib results in increased cleavage of CASP9 protein]; Arsenic Trioxide promotes the reaction [Ethacrynic Acid results in increased cleavage of CASP9 protein]; Arsenic Trioxide promotes the reaction [lonidamine results in increased cleavage of and results in increased activity of CASP9 protein]; Arsenic Trioxide promotes the reaction [Poly I-C results in increased activity of CASP9 protein]; Arsenic Trioxide promotes the reaction [Sorafenib results in increased activity of CASP9 protein]; Arsenic Trioxide results in increased cleavage of and results in increased activity of CASP9 protein; Arsenic Trioxide results in increased expression of and results in increased cleavage of CASP9 protein; BCL2 protein inhibits the reaction [Arsenic Trioxide promotes the reaction [lonidamine results in increased cleavage of and results in increased activity of CASP9 protein]]; BCL2 protein inhibits the reaction [lonidamine promotes the reaction [Arsenic Trioxide results in increased cleavage of and results in increased activity of CASP9 protein]]; BCL2L11 mutant form inhibits the reaction [Arsenic Trioxide results in increased cleavage of CASP9 protein]; Bortezomib promotes the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]; Dasatinib promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP9 protein]; Deoxyglucose promotes the reaction [Arsenic Trioxide results in increased cleavage of and results in increased activity of CASP9 protein]; Fluorouracil promotes the reaction [Arsenic Trioxide results in decreased expression of CASP9 protein]; Genistein promotes the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]; GSTP1 mutant form promotes the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP9 protein]; HSF1 protein affects the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]; KNK 437 promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP9 protein]; lonidamine promotes the reaction [Arsenic Trioxide results in increased cleavage of and results in increased activity of CASP9 protein]; MAPK8 protein affects the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]; MCL1 mutant form promotes the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP9 protein]; MIR203A protein promotes the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]; Poly I-C promotes the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]; salvin promotes the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]; SB 203580 inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein]; Sorafenib promotes the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]; STMN1 inhibits the reaction [Arsenic Trioxide results in increased cleavage of CASP9 protein]; TNF protein promotes the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]PMID:17237268 PMID:17374990 PMID:17673311 PMID:18281123 PMID:18387645 PMID:19371599 PMID:19408305 PMID:19695276 PMID:19771260 PMID:20219070 PMID:20471514 PMID:20534739 PMID:20605902 PMID:20657188 PMID:21418039 PMID:21518486 PMID:21655183 PMID:21889928 PMID:22496356 PMID:22753750 PMID:22963400 PMID:23041229 PMID:23082001 PMID:23239002 PMID:23737871 PMID:24377552 PMID:25258189 PMID:25416439 PMID:25815518 PMID:26160715 PMID:29266867 PMID:30472098
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