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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:7989
Term: pepstatin A
Definition: A pentapeptide isolated from Streptomyces testaceus. It is a potent inhibitor of aspartyl proteases.
Chemical ID: MESH:C031375
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9multiple interactionsEXP 6480464CTDpepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP9 protein]PMID:28378122
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTDpepstatin inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein modified form]; pepstatin inhibits the reaction [syringic acid analog results in increased secretion of CASP9 protein]PMID:31226464 PMID:34523043
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