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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:9144
Term: silibinin
Definition: A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.
Chemical ID: MESH:C440975
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfmultiple interactionsEXP 6480464CTDSilybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein]; Silybin inhibits the reaction [Fluorouracil results in increased expression of TNF protein]PMID:28619387 PMID:37335224
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDSilybin inhibits the reaction [IL1B protein results in increased expression of TNF mRNA]; Silybin inhibits the reaction [IL1B protein results in increased secretion of TNF protein]PMID:28914761
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