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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:51348
Term: tetraphene
Definition: An angular ortho-fused polycyclic arene consisting of four fused benzene rings.
Chemical ID: MESH:C030935
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDbenz(a)anthracene results in increased expression of TNF mRNAPMID:25433334
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTD[benz(a)anthracene co-treated with TNF protein] results in increased activity of AHR protein; [benz(a)anthracene co-treated with TNF protein] results in increased expression of CCL2 mRNA; [benz(a)anthracene co-treated with TNF protein] results in increased expression of CXCL8 mRNA; [benz(a)anthracene co-treated with TNF protein] results in increased expression of CYP1B1 mRNA; [benz(a)anthracene co-treated with TNF protein] results in increased expression of IL6 mRNA; [benz(a)anthracene co-treated with TNF protein] results in increased expression of NEDD9 mRNA; [benz(a)anthracene co-treated with TNF protein] results in increased expression of PTGS2 mRNA; [benz(a)anthracene co-treated with TNF protein] results in increased expression of TGFB1 mRNA; [benz(a)anthracene co-treated with TNF protein] results in increased expression of TNF mRNA; [benz(a)anthracene co-treated with TNF protein] results in increased phosphorylation of and results in increased degradation of NFKBIA protein; [benz(a)anthracene co-treated with TNF protein] results in increased secretion of IL6 protein; AHR protein affects the reaction [[benz(a)anthracene co-treated with TNF protein] results in increased expression of IL6]; Curcumin inhibits the reaction [[benz(a)anthracene co-treated with TNF protein] results in increased expression of IL6 mRNA]; RELA protein affects the reaction [[benz(a)anthracene co-treated with TNF protein] results in increased expression of IL6]PMID:23396138
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