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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3694
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc18a2
Name: solute carrier family 18 member A2
Acc ID: CHEBI:6887
Term: methylphenidate
Definition: A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
Chemical ID: MESH:D008774
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc18a2decreases activityISOSLC18A2 (Homo sapiens)6480464CTDMethylphenidate results in decreased activity of SLC18A2 proteinPMID:33378168
Slc18a2decreases expressionISOSlc18a2 (Mus musculus)6480464CTDMethylphenidate results in decreased expression of SLC18A2 mRNAPMID:22470460
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