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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3648
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sdc1
Name: syndecan 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sdc1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of SDC1 mRNAPMID:16054898 PMID:18796159 PMID:20959002 PMID:21215274 PMID:22342509 PMID:27136898
Sdc1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SDC1 mRNAPMID:34747641
Sdc1affects expressionISOSdc1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SDC1 mRNAPMID:21570461
Sdc1decreases expressionISOSdc1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SDC1 mRNAPMID:17586704 PMID:18172886 PMID:18796159 PMID:27562557
Sdc1multiple interactionsISOSDC1 (Homo sapiens)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of SDC1 mRNAPMID:29704546
Sdc1multiple interactionsISOSdc1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of SDC1 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SDC1 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [CpG ODN 1826 results in increased expression of SDC1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of SDC1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [resiquimod results in increased expression of SDC1 protein]PMID:16214954 PMID:17942748 PMID:20348231
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