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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3631
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scn1b
Name: sodium voltage-gated channel beta subunit 1
Acc ID: CHEBI:8107
Term: phenytoin
Definition: A imidazolidine-2,4-dione that consists of hydantoin bearing two phenyl substituents at position 5.
Chemical ID: MESH:D010672
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scn1baffects bindingISOSCN1B (Homo sapiens)6480464CTDPhenytoin binds to [SCN1B protein binds to SCN3A protein]PMID:15922564
Scn1bdecreases response to substanceISOSCN1B (Homo sapiens)6480464CTDSCN1B protein mutant form results in decreased susceptibility to PhenytoinPMID:15922564
Scn1bmultiple interactionsISOSCN1B (Homo sapiens)6480464CTDPhenytoin results in decreased activity of [SCN1B protein binds to SCN3A protein]PMID:15922564
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