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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-trans-(S)-allethrin | multiple interactions | EXP | | 6480464 | bioallethrin affects the reaction [[SCN2B protein co-treated with SCN1B protein co-treated with SCN8A protein mutant form] results in increased transport of Sodium] | CTD | PMID:22465659 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SCN1B mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SCN1B mRNA | CTD | PMID:22298810 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:737154 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SCN1B mRNA | CTD | PMID:20188158 | acetylsalicylic acid | increases expression | ISO | RGD:1350483 | 6480464 | Aspirin results in increased expression of SCN1B mRNA | CTD | PMID:11906190 | amiodarone | decreases expression | ISO | RGD:737154 | 6480464 | Amiodarone results in decreased expression of SCN1B mRNA | CTD | PMID:15520326 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SCN1B mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | ISO | RGD:737154 | 6480464 | Benzo(a)pyrene results in decreased expression of SCN1B mRNA | CTD | PMID:21715664 | bis(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in increased expression of SCN1B mRNA | CTD | PMID:20920545 | calcitriol | multiple interactions | ISO | RGD:1350483 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of SCN1B mRNA | CTD | PMID:21592394 | calcitriol | increases expression | ISO | RGD:1350483 | 6480464 | Calcitriol results in increased expression of SCN1B mRNA | CTD | PMID:21592394 | carmustine | increases expression | EXP | | 6480464 | Carmustine results in increased expression of SCN1B mRNA | CTD | PMID:16005536 | cobalt dichloride | increases expression | ISO | RGD:1350483 | 6480464 | cobaltous chloride results in increased expression of SCN1B mRNA | CTD | PMID:19376846 | cobalt dichloride | decreases expression | ISO | RGD:1350483 | 6480464 | cobaltous chloride results in decreased expression of SCN1B mRNA | CTD | PMID:19320972 | cyclosporin A | decreases expression | ISO | RGD:1350483 | 6480464 | Cyclosporine results in decreased expression of SCN1B mRNA | CTD | PMID:20106945 | cyfluthrin | multiple interactions | EXP | | 6480464 | cyfluthrin affects the reaction [[SCN2A1 protein binds to SCN1B protein] which results in increased transport of Sodium] | CTD | PMID:18538810 | cypermethrin | multiple interactions | EXP | | 6480464 | cypermethrin affects the reaction [[SCN2A1 protein binds to SCN1B protein] which results in increased transport of Sodium] | CTD | PMID:18538810 | cypermethrin | multiple interactions | EXP | | 6480464 | SCN1B protein promotes the reaction [cypermethrin binds to SCN2A1 protein] | CTD | PMID:9863771 | fenpropathrin | multiple interactions | EXP | | 6480464 | fenpropathrin affects the reaction [[SCN2A1 protein binds to SCN1B protein] which results in increased transport of Sodium] | CTD | PMID:18538810 | fenvalerate | multiple interactions | EXP | | 6480464 | fenvalerate affects the reaction [[SCN2A1 protein binds to SCN1B protein] which results in increased transport of Sodium] | CTD | PMID:18538810 | hydroquinone O-beta-D-glucopyranoside | increases expression | ISO | RGD:1350483 | 6480464 | Arbutin results in increased expression of SCN1B mRNA | CTD | PMID:17103032 | methotrexate | increases expression | EXP | | 6480464 | Methotrexate results in increased expression of SCN1B mRNA | CTD | PMID:16005536 | paracetamol | affects expression | ISO | RGD:737154 | 6480464 | Acetaminophen affects the expression of SCN1B mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | RGD:1350483 | 6480464 | Acetaminophen results in decreased expression of SCN1B mRNA | CTD | PMID:22230336 | phenytoin | affects binding | ISO | RGD:1350483 | 6480464 | Phenytoin binds to [SCN1B protein binds to SCN3A protein] | CTD | PMID:15922564 | phenytoin | decreases response to substance | ISO | RGD:1350483 | 6480464 | SCN1B protein mutant form results in decreased susceptibility to Phenytoin | CTD | PMID:15922564 | phenytoin | multiple interactions | ISO | RGD:1350483 | 6480464 | Phenytoin results in decreased activity of [SCN1B protein binds to SCN3A protein] | CTD | PMID:15922564 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of SCN1B mRNA | CTD | PMID:19162173 | prostaglandin F2alpha | increases expression | EXP | | 6480464 | Dinoprost results in increased expression of SCN1B mRNA | CTD | PMID:11517196 | sodium atom | multiple interactions | EXP | | 6480464 | cyfluthrin affects the reaction [[SCN2A1 protein binds to SCN1B protein] which results in increased transport of Sodium]; more ... | CTD | PMID:18538810 | sodium atom | multiple interactions | EXP | | 6480464 | 2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate inhibits the reaction [[SCN2A1 protein co-treated with SCN2B protein co-treated with SCN1B protein] results in increased transport of Sodium] | CTD | PMID:19026681 | sodium atom | multiple interactions | ISO | RGD:1350483 | 6480464 | [SCN3A protein co-treated with SCN2B protein co-treated with SCN1B protein] results in increased transport of Sodium; more ... | CTD | PMID:19026681 | sodium atom | multiple interactions | EXP | | 6480464 | 2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate affects the reaction [[SCN2B protein co-treated with SCN1B protein co-treated with SCN8A protein mutant form] results in increased transport of Sodium]; more ... | CTD | PMID:22465659 | sodium atom | multiple interactions | EXP | | 6480464 | [SCN2A protein binds to SCN1B protein] which affects the transport of Sodium | CTD | PMID:9236205 | testosterone | multiple interactions | ISO | RGD:1350483 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of SCN1B mRNA | CTD | PMID:21592394 | testosterone | increases expression | ISO | RGD:1350483 | 6480464 | Testosterone results in increased expression of SCN1B mRNA | CTD | PMID:21592394 | tetrodotoxin | multiple interactions | EXP | | 6480464 | Tetrodotoxin results in decreased activity of [SCN2A protein binds to SCN1B protein] | CTD | PMID:9236205 | tetrodotoxin | multiple interactions | EXP | | 6480464 | Tetrodotoxin results in decreased activity of [SCN8A protein binds to SCN1B protein binds to SCN2B protein] | CTD | PMID:21983428 | tioguanine | increases expression | EXP | | 6480464 | Thioguanine results in increased expression of SCN1B mRNA | CTD | PMID:16005536 | valproic acid | affects expression | ISO | RGD:737154 | 6480464 | Valproic Acid affects the expression of SCN1B mRNA | CTD | PMID:17292431 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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References - curated| 1. |
Deschenes I, etal., J Mol Cell Cardiol. 2008 Sep;45(3):336-46. Epub 2008 May 12. |
| 2. |
Dhar Malhotra J, etal., Circulation. 2001 Mar 6;103(9):1303-10. |
| 3. |
Dib-Hajj SD and Waxman SG, FEBS Lett 1995 Dec 27;377(3):485-8. |
| 4. |
Isom LL, etal., Science 1992 May 8;256(5058):839-42. |
| 5. |
Kazen-Gillespie KA, etal., J Biol Chem 2000 Jan 14;275(2):1079-88. |
| 6. |
MGD data from the GO Consortium |
| 7. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 8. |
Oh Y and Waxman SG, Proc Natl Acad Sci U S A 1994 Oct 11;91(21):9985-9. |
| 9. |
RGD automated data pipeline |
| 10. |
RGD automated import pipeline for gene-chemical interactions |
| 11. |
RGD Automated Pipelines |
| 12. |
Salem KA, etal., Exp Physiol. 2012 May 11. |
| 13. |
Tan J and Soderlund DM, Neurotoxicology. 2009 Jan;30(1):81-9. Epub 2008 Nov 5. |
| 14. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 15. |
Wang YW, etal., Chin Med J (Engl). 2007 Apr 20;120(8):721-3. |
References - uncuratedRGD Disease Portals| Scn1b has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Scn1b (Rattus norvegicus) |
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| SCN1B (Homo sapiens) |
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| Scn1b (Mus musculus) |
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Position Markers| U85786 |
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| PMC15797P1 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001271045 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001271046 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_017288 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06004313 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01004589 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF182949 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC094523 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473979 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ215379 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ216374 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L34417 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L48688 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M91808 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_017288 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_058984 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001257974 | (Get FASTA) |
| NP_001257975 | (Get FASTA) | |
| NP_058984 | (Get FASTA) | |
| GenBank Protein | AAA88513 | (Get FASTA) |
| AAB02428 | (Get FASTA) | |
| AAF25186 | (Get FASTA) | |
| AAH94523 | (Get FASTA) | |
| EDM07660 | (Get FASTA) | |
| EDM07661 | (Get FASTA) | |
| EDM07662 | (Get FASTA) | |
| Q00954 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000021102 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000028653 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000028653 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 29686 | ENTREZGENE |
| Gene3D-CATH | Ig-like_fold | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000021102 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 810 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7316686 | IMAGE-MGC_LOAD |
| InterPro | Ig-like_fold | UniProtKB/Swiss-Prot |
| Immunoglobulin | UniProtKB/Swiss-Prot | |
| Na_channel_b1/b3 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:29686 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:105455 | IMAGE-MGC_LOAD |
| PANTHER | PTHR10546 | UniProtKB/Swiss-Prot |
| Pfam | PF00047 | UniProtKB/Swiss-Prot |
| PharmGKB | SCN1B | RGD |
| PROSITE | IG_LIKE; FALSE_NEG | UniProtKB/Swiss-Prot |
| TIGR | TC217838 | |
| UniGene | Rn.4958 | ENTREZGENE |
| UniProt | Q9QXU3_RAT | UniProtKB/TrEMBL |
| SCN1B_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2006-03-30 | Scn1b | sodium channel, voltage-gated, type I, beta | sodium channel, voltage-gated, type I, beta polypeptide | Name updated | 10779 | APPROVED | |
| 2003-04-09 | Scn1b | sodium channel, voltage-gated, type I, beta polypeptide | sodium channel, voltage-gated, type 1, beta polypeptide | Symbol and Name status set to approved | 2576 | APPROVED | |
| 2002-06-10 | Scn1b | sodium channel, voltage-gated, type 1, beta polypeptide | Name updated | 1489 | PROVISIONAL |
| More on Scn1b | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3631 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.