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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3535
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rarb
Name: retinoic acid receptor, beta
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rarbaffects expressionISORarb (Mus musculus)6480464CTDValproic Acid affects the expression of RARB mRNAPMID:22045034
Rarbaffects methylationISORARB (Homo sapiens)6480464CTDValproic Acid affects the methylation of RARB genePMID:29501571
Rarbdecreases methylationISORARB (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of RARB genePMID:29154799
Rarbincreases expressionISORARB (Homo sapiens)6480464CTDValproic Acid results in increased expression of RARB mRNAPMID:23179753 PMID:24383497 PMID:24935251 PMID:29501571
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