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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3342
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plat
Name: plasminogen activator, tissue type
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Platdecreases activityEXP 6480464CTDDexamethasone results in decreased activity of PLAT proteinPMID:3127913
Platmultiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [IL1B protein results in increased activity of PLAT protein]; Dexamethasone inhibits the reaction [IL1B protein results in increased expression of PLAT mRNA]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [IL1B protein results in increased expression of PLAT mRNA]]; RU 43044 inhibits the reaction [Dexamethasone inhibits the reaction [IL1B protein results in increased expression of PLAT mRNA]]PMID:15963473
Platdecreases activityISOPLAT (Homo sapiens)6480464CTDDexamethasone results in decreased activity of PLAT proteinPMID:1656149
Platdecreases expressionISOPLAT (Homo sapiens)6480464CTDDexamethasone results in decreased expression of PLAT mRNAPMID:25047013
Platmultiple interactionsISOPlat (Mus musculus)6480464CTD[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PLAT mRNAPMID:16054899
Platmultiple interactionsISOPLAT (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of PLAT mRNAPMID:28628672
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