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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pgr
Name: progesterone receptor
Acc ID: CHEBI:132407
Term: chrysen-6-ol
Definition: A hydroxychrysene that is chrysene in which the hydrogen at position 6 has been replaced by a hydroxy group. It is a metabolite of the polycyclic aromatic hydrocarbon chrysene.
Chemical ID: MESH:C087203
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgrmultiple interactionsISOPGR (Homo sapiens)6480464CTD6-hydroxychrysene inhibits the reaction [Progesterone binds to PGR protein]; [Progesterone co-treated with 6-hydroxychrysene] results in decreased expression of PGR mRNAPMID:9144411
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