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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3234
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Oprm1
Name: opioid receptor, mu 1
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Oprm1increases expressionISOOPRM1 (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased expression of OPRM1 mRNAPMID:11901219
Oprm1multiple interactionsISOOprm1 (Mus musculus)6480464CTD[Tetradecanoylphorbol Acetate co-treated with Calcium] inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]PMID:18652891
Oprm1multiple interactionsISOOPRM1 (Homo sapiens)6480464CTDSulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OPRM1 mRNA]PMID:11901219
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