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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3234
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Oprm1
Name: opioid receptor, mu 1
Acc ID: CHEBI:180536
Term: 7-Hydroxymitragynine
Definition: null
Chemical ID: MESH:C482678
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Oprm1affects bindingISOOprm1 (Mus musculus)6480464CTD7-hydroxymitragynine binds to OPRM1 proteinPMID:27192616
Oprm1increases activityISOOPRM1 (Homo sapiens)6480464CTD7-hydroxymitragynine results in increased activity of OPRM1 proteinPMID:32734307
Oprm1multiple interactionsISOOPRM1 (Homo sapiens)6480464CTD7-hydroxymitragynine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]; 7-hydroxymitragynine binds to and results in increased activity of OPRM1 proteinPMID:27192616
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