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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3194
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nppb
Name: natriuretic peptide B
Acc ID: CHEBI:9927
Term: valsartan
Definition: A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.
Chemical ID: MESH:C081489
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nppbdecreases expressionEXP 6480464CTDValsartan results in decreased expression of NPPB mRNAPMID:11136700
Nppbmultiple interactionsEXP 6480464CTD[Valsartan co-treated with benazepril] results in decreased expression of NPPB mRNAPMID:11136700
Nppbdecreases expressionISONPPB (Homo sapiens)6480464CTDValsartan results in decreased expression of NPPB proteinPMID:12417542
Nppbmultiple interactionsISONppb (Mus musculus)6480464CTDValsartan inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]PMID:31009642
Nppbmultiple interactionsISONPPB (Homo sapiens)6480464CTDValsartan inhibits the reaction [CHOP protocol results in increased expression of NPPB protein]PMID:16247790
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