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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3187
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Notch1
Name: notch receptor 1
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Notch1decreases expressionISONOTCH1 (Homo sapiens)6480464CTDCurcumin results in decreased expression of NOTCH1 mRNA; Curcumin results in decreased expression of NOTCH1 proteinPMID:17927689 PMID:18640131
Notch1multiple interactionsISONOTCH1 (Homo sapiens)6480464CTD[Curcumin co-treated with Isoflavones] results in decreased expression of NOTCH1 proteinPMID:18640131
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