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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3multiple interactionsEXP 6480464CTD[kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of NOS3 protein; [Lipopolysaccharides co-treated with TNF protein] results in increased expression of NOS3 protein; [MK 2206 inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of NOS3 protein; NOS3 protein promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]PMID:15583003 PMID:36049518
Nos3decreases expressionISONos3 (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of NOS3 proteinPMID:23170834
Nos3multiple interactionsISONos3 (Mus musculus)6480464CTDESR1 protein affects the reaction [Lipopolysaccharides affects the expression of NOS3 mRNA]; ESR1 protein affects the reaction [Lipopolysaccharides affects the expression of NOS3 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of NOS3 protein]PMID:17158209 PMID:23170834
Nos3multiple interactionsISONOS3 (Homo sapiens)6480464CTDLipopolysaccharides promotes the reaction [Nickel results in decreased expression of [NOS3 protein binds to NOS3 protein]]PMID:23788629
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