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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3171
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkbia
Name: NFKB inhibitor alpha
Acc ID: CHEBI:53001
Term: nickel sulfate
Definition: A metal sulfate having nickel(2+) as the metal ion.
Chemical ID: MESH:C029938
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkbiaincreases degradationISONFKBIA (Homo sapiens)6480464CTDnickel sulfate results in increased degradation of NFKBIA proteinPMID:17636246 PMID:19101624
Nfkbiaincreases expressionISONFKBIA (Homo sapiens)6480464CTDnickel sulfate results in increased expression of NFKBIA mRNAPMID:16780908 PMID:22714537
Nfkbiamultiple interactionsISONFKBIA (Homo sapiens)6480464CTD[nickel sulfate results in increased degradation of NFKBIA protein] which results in increased activity of RELA protein; BAY 11-7085 inhibits the reaction [nickel sulfate results in increased degradation of NFKBIA protein]PMID:17636246
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