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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3031
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad2
Name: SMAD family member 2
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad2multiple interactionsEXP 6480464CTD[Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased phosphorylation of SMAD2 protein; Resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD2 protein]PMID:21300041 PMID:31062909
Smad2decreases expressionISOSMAD2 (Homo sapiens)6480464CTDresveratrol results in decreased expression of SMAD2 mRNA; resveratrol results in decreased expression of SMAD2 proteinPMID:18089832 PMID:25721869
Smad2decreases phosphorylationISOSmad2 (Mus musculus)6480464CTDresveratrol results in decreased phosphorylation of SMAD2 proteinPMID:21679764
Smad2multiple interactionsISOSmad2 (Mus musculus)6480464CTDresveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of SMAD2 protein]PMID:25234611
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