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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3031
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad2
Name: SMAD family member 2
Acc ID: CHEBI:79068
Term: crocin-1
Definition: A diester that is crocetin in which both of the carboxy groups have been converted to their gentiobiosyl esters. It is one of the water-soluble yellow-red pigments of saffron and is used as a spice for flavouring and colouring food. Note that in India, the term 'Crocin' is also used by GlaxoSmithKline as a brand-name for paracetamol.
Chemical ID: MESH:C029036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad2decreases expressionEXP 6480464CTDcrocin results in decreased expression of SMAD2 proteinPMID:32259551
Smad2multiple interactionsEXP 6480464CTDCisplatin inhibits the reaction [crocin results in decreased expression of SMAD2 protein]; crocin inhibits the reaction [Cisplatin results in increased expression of SMAD2 protein]PMID:32259551
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