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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2996
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ldha
Name: lactate dehydrogenase A
Acc ID: CHEBI:68931
Term: bruceine D
Definition: A quassinoid that is 13,20-epoxypicras-3-ene substituted by hydroxy groups at positions 1, 11, 12, 14 and 15 and oxo groups at positions 2 and 16. Isolated from the ethanol extract of the stem of Brucea mollis, it exhibits cytotoxic activity.
Chemical ID: MESH:C030412
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ldhadecreases expressionISOLDHA (Homo sapiens)6480464CTDbruceine D results in decreased expression of LDHA proteinPMID:34900531
Ldhamultiple interactionsISOLDHA (Homo sapiens)6480464CTDbruceine D affects the reaction [Oxygen deficiency affects the expression of LDHA protein]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of LDHA protein]]PMID:34900531
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