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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2959
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnj6
Name: potassium inwardly-rectifying channel, subfamily J, member 6
Acc ID: CHEBI:4887
Term: ethosuximide
Definition: A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.
Chemical ID: MESH:D005013
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnj6multiple interactionsEXP 6480464CTDEthosuximide inhibits the reaction [Ethanol promotes the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]]PMID:18977371
Kcnj6multiple interactionsISOKcnj6 (Mus musculus)6480464CTDEthosuximide inhibits the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]PMID:18977371
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