Kcnj6 (potassium inwardly-rectifying channel, subfamily J, member 6) - Rat Genome Database

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Gene: Kcnj6 (potassium inwardly-rectifying channel, subfamily J, member 6) Mus musculus
Analyze
Symbol: Kcnj6
Name: potassium inwardly-rectifying channel, subfamily J, member 6
RGD ID: 731945
MGI Page MGI
Description: Enables G-protein activated inward rectifier potassium channel activity and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Acts upstream of or within monoatomic ion transmembrane transport; regulation of presynaptic membrane potential; and thyroid hormone metabolic process. Is active in parallel fiber to Purkinje cell synapse and presynaptic membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in alcohol use disorder and heroin dependence. Orthologous to human KCNJ6 (potassium inwardly rectifying channel subfamily J member 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BIR1; G protein-activated inward rectifier potassium channel 2; G-protein-coupled inward rectifier K+ channel 2-1; G-protein-coupled inward rectifier K+ channel 2-A; G-protein-coupled inward rectifier K+ channel 2-B; G-protein-coupled inward rectifier K+ channel 2-C; GIR; GIRK-2; GIRK2; inward rectifier K(+) channel Kir3.2; KATP2; KCNJ; KCNJ7; Kir3; Kir3.2; potassium channel, inwardly rectifying subfamily J member 6; potassium inwardly-rectifying channel J6; weaver; wv
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391694,545,839 - 94,798,719 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1694,549,495 - 94,798,560 (-)EnsemblGRCm39 Ensembl
GRCm381694,744,980 - 94,997,696 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1694,748,636 - 94,997,701 (-)EnsemblGRCm38mm10GRCm38
MGSCv371694,970,290 - 95,219,303 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361694,857,497 - 95,106,494 (-)NCBIMGSCv36mm8
Celera1695,836,339 - 96,085,607 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1655.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cell migration  (IAGP)
abnormal cerebellar cortex morphology  (IAGP)
abnormal cerebellar granule cell morphology  (IAGP)
abnormal cerebellar granule layer morphology  (IAGP)
abnormal cerebellar lobule formation  (IAGP)
abnormal cerebellar molecular layer  (IAGP)
abnormal cerebellar Purkinje cell layer  (IAGP)
abnormal cerebellum development  (IEA)
abnormal cerebellum external granule cell layer morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebellum vermis morphology  (IAGP)
abnormal CNS synaptic transmission  (IAGP)
abnormal cochlear VIII nucleus morphology  (IAGP)
abnormal epididymis morphology  (IAGP)
abnormal gait  (IEA)
abnormal hippocampal mossy fiber morphology  (IAGP)
abnormal hippocampus pyramidal cell layer  (IAGP)
abnormal ion homeostasis  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal male germ cell morphology  (IAGP)
abnormal maternal nurturing  (IEA)
abnormal motor capabilities/coordination/movement  (IEA)
abnormal motor coordination/balance  (IEA)
abnormal nervous system electrophysiology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal Purkinje cell dendrite morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal seminiferous tubule epithelium morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal Sertoli cell morphology  (IAGP)
abnormal sperm motility  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal substantia nigra pars compacta morphology  (IAGP)
abnormal synaptic glutamate release  (IAGP)
abnormal synaptic neurotransmitter level  (IAGP)
abnormal synaptic transmission  (IAGP)
abnormal testis morphology  (IAGP)
absent cerebellar lobules  (IEA)
absent cerebellum fissure  (IEA)
ataxia  (IAGP)
azoospermia  (IAGP)
behavioral despair  (IAGP)
decreased anxiety-related response  (IEA)
decreased body size  (IEA)
decreased body weight  (IAGP)
decreased dopamine level  (IAGP)
decreased dopaminergic neuron number  (IAGP)
decreased food intake  (IEA)
decreased Purkinje cell number  (IAGP)
decreased taurine level  (IAGP)
delaminated Purkinje cell layer  (IAGP)
ectopic hippocampus pyramidal cells  (IAGP)
ectopic Purkinje cell  (IAGP)
environmentally induced seizures  (IAGP)
globozoospermia  (IAGP)
hyperactivity  (IEA)
hypotonia  (IAGP)
impaired righting response  (IAGP)
increased apoptosis  (IAGP)
increased circulating amylase level  (IEA)
increased exploration in new environment  (IEA)
increased noradrenaline level  (IAGP)
increased Purkinje cell number  (IEA)
increased susceptibility to pharmacologically induced seizures  (IAGP)
induced hyperactivity  (IEA)
lethality at weaning, incomplete penetrance  (IEA)
male infertility  (IAGP)
oligozoospermia  (IAGP)
premature death  (IAGP)
reduced female fertility  (IEA)
reduced male fertility  (IEA)
retropulsion  (IAGP)
seizures  (IAGP)
seminiferous tubule degeneration  (IAGP)
small cerebellum  (IAGP)
thin cerebellar granule layer  (IAGP)
tonic-clonic seizures  (IAGP)
tremors  (IAGP)
weaving  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome. Best TK, etal., Exp Neurol. 2012 Feb;233(2):749-57. Epub 2011 Dec 8.
2. KCNJ6 is associated with adult alcohol dependence and involved in gene x early life stress interactions in adolescent alcohol drinking. Clarke TK, etal., Neuropsychopharmacology. 2011 May;36(6):1142-8. Epub 2011 Feb 9.
3. A KCNJ6 (Kir3.2, GIRK2) gene polymorphism modulates opioid effects on analgesia and addiction but not on pupil size. Lotsch J, etal., Pharmacogenet Genomics. 2010 May;20(5):291-7.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1003203   PMID:1148865   PMID:1150661   PMID:1252920   PMID:1282111   PMID:1324769   PMID:1356243   PMID:1365447   PMID:1446244   PMID:1483388   PMID:1528352   PMID:1547486  
PMID:1565842   PMID:1781951   PMID:1801100   PMID:1912584   PMID:2027034   PMID:2077109   PMID:2123001   PMID:2230805   PMID:2280222   PMID:2293612   PMID:2575584   PMID:2707487  
PMID:2723742   PMID:2901364   PMID:3619071   PMID:3882972   PMID:4118891   PMID:4128371   PMID:4561458   PMID:4761656   PMID:6123371   PMID:6127146   PMID:6494907   PMID:6690983  
PMID:6811784   PMID:6960362   PMID:7062116   PMID:7119868   PMID:7321055   PMID:7391543   PMID:7477675   PMID:7498373   PMID:7499385   PMID:7550328   PMID:7550338   PMID:7568088  
PMID:7595495   PMID:7637577   PMID:7640872   PMID:7656429   PMID:7672013   PMID:7693502   PMID:7702616   PMID:7722620   PMID:7728332   PMID:7729594   PMID:7756729   PMID:7760215  
PMID:7798913   PMID:7808217   PMID:7825062   PMID:7888095   PMID:7888149   PMID:7898605   PMID:7898606   PMID:7905025   PMID:7912161   PMID:7926018   PMID:7932867   PMID:7942094  
PMID:7965086   PMID:7969746   PMID:7969910   PMID:8013566   PMID:8026336   PMID:8081012   PMID:8100981   PMID:8126599   PMID:8129695   PMID:8132866   PMID:8172626   PMID:8177535  
PMID:8230318   PMID:8287193   PMID:8326827   PMID:8377223   PMID:8406490   PMID:8469990   PMID:8485453   PMID:8490719   PMID:8510506   PMID:8541477   PMID:8573147   PMID:8574680  
PMID:8575083   PMID:8584226   PMID:8614556   PMID:8622783   PMID:8630252   PMID:8663983   PMID:8665663   PMID:8678987   PMID:8706831   PMID:8707831   PMID:8719615   PMID:8735215  
PMID:8751059   PMID:8774449   PMID:8789947   PMID:8800659   PMID:8808466   PMID:8815896   PMID:8855331   PMID:8889548   PMID:8915827   PMID:8922675   PMID:8929423   PMID:8986828  
PMID:8989525   PMID:9023358   PMID:9028770   PMID:9037414   PMID:9037545   PMID:9042576   PMID:9120059   PMID:9125426   PMID:9133390   PMID:9141074   PMID:9178034   PMID:9204476  
PMID:9210872   PMID:9224846   PMID:9244437   PMID:9342388   PMID:9403713   PMID:9406977   PMID:9459542   PMID:9460703   PMID:9514513   PMID:9520333   PMID:9562526   PMID:9570785  
PMID:9590553   PMID:9592081   PMID:9721208   PMID:9733904   PMID:9750193   PMID:9754955   PMID:9756100   PMID:9852586   PMID:9855287   PMID:9860268   PMID:9867243   PMID:9873201  
PMID:9882481   PMID:9926858   PMID:10022826   PMID:10051229   PMID:10084680   PMID:10336081   PMID:10338272   PMID:10349636   PMID:10364438   PMID:10433930   PMID:10443552   PMID:10446341  
PMID:10464361   PMID:10479699   PMID:10515259   PMID:10516303   PMID:10544173   PMID:10555786   PMID:10555787   PMID:10562331   PMID:10619558   PMID:10766925   PMID:10800965   PMID:10837899  
PMID:10934250   PMID:10956667   PMID:10960685   PMID:10960686   PMID:10982471   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11374901   PMID:11434974   PMID:11454913   PMID:11519718  
PMID:11564458   PMID:11596045   PMID:11600321   PMID:11700294   PMID:11823889   PMID:11891065   PMID:12009769   PMID:12040038   PMID:12221097   PMID:12270032   PMID:12297500   PMID:12408845  
PMID:12466851   PMID:12466854   PMID:12466855   PMID:12477932   PMID:12493843   PMID:12496346   PMID:12499858   PMID:12707131   PMID:12721779   PMID:12786972   PMID:12843272   PMID:14519489  
PMID:14681479   PMID:14724391   PMID:15028774   PMID:15240766   PMID:15337313   PMID:15531086   PMID:15544578   PMID:15694268   PMID:15723059   PMID:15790531   PMID:15814785   PMID:15846777  
PMID:15888923   PMID:16120781   PMID:16141072   PMID:16141073   PMID:16221865   PMID:16299504   PMID:16339040   PMID:16387438   PMID:16396906   PMID:16420440   PMID:16423897   PMID:16499884  
PMID:16523244   PMID:16602821   PMID:16624949   PMID:16626633   PMID:16708025   PMID:16750479   PMID:16783527   PMID:16844307   PMID:16857990   PMID:16985003   PMID:17093086   PMID:17093127  
PMID:17122050   PMID:17420263   PMID:17582722   PMID:17663432   PMID:17826805   PMID:17953485   PMID:17965710   PMID:18088366   PMID:18194467   PMID:18303085   PMID:18400906   PMID:18702733  
PMID:19200061   PMID:19558451   PMID:19561601   PMID:20393461   PMID:20453851   PMID:20460368   PMID:20557431   PMID:21057506   PMID:21713770   PMID:21795707   PMID:21873635   PMID:22054410  
PMID:22098295   PMID:22252428   PMID:22528965   PMID:22534482   PMID:22889265   PMID:23022491   PMID:23040084   PMID:23041116   PMID:23169654   PMID:23219908   PMID:23261870   PMID:23637192  
PMID:23804514   PMID:23818182   PMID:24244570   PMID:24449842   PMID:24811384   PMID:24952961   PMID:25049222   PMID:25127144   PMID:25217379   PMID:25798587   PMID:25907855   PMID:25948263  
PMID:25956878   PMID:26490875   PMID:26558769   PMID:26612516   PMID:26852701   PMID:27074662   PMID:27462820   PMID:27468917   PMID:27599866   PMID:28131769   PMID:28196855   PMID:28213520  
PMID:28342823   PMID:28461162   PMID:28487514   PMID:29180115   PMID:29321139   PMID:29915136   PMID:29929098   PMID:30578891   PMID:30689541   PMID:30837265   PMID:30902995   PMID:31371375  
PMID:31850343   PMID:32372643   PMID:32853992   PMID:33402420   PMID:34636409   PMID:34681766   PMID:34881429   PMID:35314385   PMID:35914814   PMID:36674903   PMID:37594983   PMID:38187761  
PMID:38266108  


Genomics

Comparative Map Data
Kcnj6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391694,545,839 - 94,798,719 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1694,549,495 - 94,798,560 (-)EnsemblGRCm39 Ensembl
GRCm381694,744,980 - 94,997,696 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1694,748,636 - 94,997,701 (-)EnsemblGRCm38mm10GRCm38
MGSCv371694,970,290 - 95,219,303 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361694,857,497 - 95,106,494 (-)NCBIMGSCv36mm8
Celera1695,836,339 - 96,085,607 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1655.44NCBI
KCNJ6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382137,607,373 - 37,916,457 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2137,607,373 - 38,121,345 (-)EnsemblGRCh38hg38GRCh38
GRCh372138,979,675 - 39,288,760 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362137,918,655 - 38,210,566 (-)NCBINCBI36Build 36hg18NCBI36
Build 342137,918,656 - 38,210,566NCBI
Celera2124,194,896 - 24,487,265 (-)NCBICelera
Cytogenetic Map21q22.13NCBI
HuRef2124,470,127 - 24,761,921 (-)NCBIHuRef
CHM1_12138,557,922 - 38,850,112 (-)NCBICHM1_1
T2T-CHM13v2.02135,989,771 - 36,299,971 (-)NCBIT2T-CHM13v2.0
Kcnj6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81147,531,312 - 47,778,348 (-)NCBIGRCr8
mRatBN7.21134,061,702 - 34,308,758 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,061,708 - 34,308,758 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,718,859 - 42,966,801 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01135,390,234 - 35,638,172 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01134,536,231 - 34,783,241 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01135,011,007 - 35,262,362 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1135,024,196 - 35,099,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01138,602,645 - 38,692,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,025,118 - 35,116,500 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11135,096,649 - 35,172,743NCBI
Celera1134,144,832 - 34,389,786 (+)NCBICelera
Cytogenetic Map11q11NCBI
Kcnj6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540736,659,627 - 36,924,024 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540736,670,824 - 36,923,960 (-)NCBIChiLan1.0ChiLan1.0
KCNJ6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22233,721,642 - 34,033,922 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12128,581,161 - 28,895,193 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02123,983,485 - 24,284,759 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12137,339,201 - 37,634,876 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2137,340,738 - 37,558,688 (-)Ensemblpanpan1.1panPan2
KCNJ6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13132,752,585 - 33,010,999 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3132,755,899 - 32,934,478 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3131,821,629 - 32,081,491 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03132,062,846 - 32,322,567 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3132,066,922 - 32,322,588 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13131,937,274 - 32,196,786 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03131,945,083 - 32,204,244 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03132,428,866 - 32,689,562 (-)NCBIUU_Cfam_GSD_1.0
Kcnj6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497132,225,573 - 32,465,141 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365005,065,107 - 5,239,854 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365005,002,668 - 5,164,511 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13201,243,609 - 201,525,820 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113201,231,803 - 201,525,943 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213211,406,250 - 211,613,586 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1281,569,659 - 81,878,047 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660549,424,667 - 9,732,757 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnj6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474525,947,561 - 26,127,171 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474525,879,671 - 26,130,998 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnj6
506 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1239
Count of miRNA genes:660
Interacting mature miRNAs:801
Transcripts:ENSMUST00000095873, ENSMUST00000099508, ENSMUST00000165538
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301125Sluc27_msusceptibility to lung cancer 27 (mouse)Not determined166160864495608764Mouse
4141113Tgq28_mtriglyceride QTL 28 (mouse)Not determined6298664696986646Mouse
1300928Etia_methanol induced activation (mouse)Not determined166331390797314016Mouse
1558740Bpq9_mblood pressure QTL 9 (mouse)Not determined166332733697327472Mouse
1302194Pgia10_mproteoglycan induced arthritis 10 (mouse)Not determined166860072298008968Mouse
1301032Tauph_mtau phosphorylation (mouse)Not determined166907613298008968Mouse
11049573Lmr18b_mleishmaniasis resistance 18b (mouse)166912761198008968Mouse
11049574Lmr18a_mleishmaniasis resistance 18a (mouse)166912761198008968Mouse
4142262Lmr18_mleishmaniasis resistance 18 (mouse)Not determined166912761198008968Mouse
11522753Cocia19_mcocaine-induced activity, QTL 19 (mouse)166925448298008968Mouse
1301598Renf2_mrenal failure 2 (mouse)Not determined167038025298008968Mouse

Markers in Region
U11859  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381694,749,031 - 94,749,186UniSTSGRCm38
MGSCv371694,970,638 - 94,970,793UniSTSGRCm37
Celera1695,836,670 - 95,836,825UniSTS
Cytogenetic Map16C4UniSTS
cM Map1668.75UniSTS
Whitehead_YAC16 UniSTS
G67822  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381694,910,284 - 94,910,432UniSTSGRCm38
MGSCv371695,131,891 - 95,132,039UniSTSGRCm37
Celera1695,998,339 - 95,998,487UniSTS
Cytogenetic Map16C4UniSTS
cM Map16 UniSTS
Kcnj6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381694,832,683 - 94,832,936UniSTSGRCm38
MGSCv371695,054,290 - 95,054,543UniSTSGRCm37
Celera1695,919,747 - 95,920,000UniSTS
Cytogenetic Map16C4UniSTS
cM Map1668.75UniSTS
D16Ium52  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381694,861,552 - 94,861,922UniSTSGRCm38
MGSCv371695,083,159 - 95,083,529UniSTSGRCm37
Celera1695,949,240 - 95,949,610UniSTS
Cytogenetic Map16C4UniSTS
cM Map1668.9UniSTS
Kcnj6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16C4UniSTS
Kcnj6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381694,762,477 - 94,762,613UniSTSGRCm38
MGSCv371694,984,084 - 94,984,220UniSTSGRCm37
Cytogenetic Map16C4UniSTS
cM Map1668.75UniSTS
Kcnj6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381694,749,022 - 94,749,261UniSTSGRCm38
MGSCv371694,970,629 - 94,970,868UniSTSGRCm37
Celera1695,836,661 - 95,836,900UniSTS
Cytogenetic Map16C4UniSTS
cM Map1668.75UniSTS
Kcnj6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16C4UniSTS
cM Map1668.75UniSTS
Kcnj6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381694,761,289 - 94,761,585UniSTSGRCm38
MGSCv371694,982,896 - 94,983,192UniSTSGRCm37
Celera1695,848,929 - 95,849,225UniSTS
Cytogenetic Map16C4UniSTS
Kcnj6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381694,832,619 - 94,832,882UniSTSGRCm38
MGSCv371695,054,226 - 95,054,489UniSTSGRCm37
Celera1695,919,683 - 95,919,946UniSTS
Cytogenetic Map16C4UniSTS
cM Map1668.75UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001025584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001025585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001025590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011246104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004939169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB029502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC165248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC165271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC171211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH011379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK015481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB277039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB591362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC120794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01061050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01061052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01061069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01217631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D86040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U11859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U63899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000095873   ⟹   ENSMUSP00000093558
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1694,549,495 - 94,798,514 (-)Ensembl
GRCm38.p6 Ensembl1694,748,636 - 94,997,655 (-)Ensembl
RefSeq Acc Id: ENSMUST00000099508   ⟹   ENSMUSP00000097108
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1694,561,928 - 94,798,555 (-)Ensembl
GRCm38.p6 Ensembl1694,761,069 - 94,997,696 (-)Ensembl
RefSeq Acc Id: ENSMUST00000165538   ⟹   ENSMUSP00000130321
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1694,623,391 - 94,657,539 (-)Ensembl
GRCm38.p6 Ensembl1694,822,532 - 94,856,680 (-)Ensembl
RefSeq Acc Id: ENSMUST00000231744
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1694,667,456 - 94,798,111 (-)Ensembl
GRCm38.p6 Ensembl1694,866,597 - 94,997,252 (-)Ensembl
RefSeq Acc Id: ENSMUST00000232128
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1694,632,589 - 94,798,560 (-)Ensembl
GRCm38.p6 Ensembl1694,831,730 - 94,997,701 (-)Ensembl
RefSeq Acc Id: ENSMUST00000232403
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1694,632,589 - 94,798,442 (-)Ensembl
GRCm38.p6 Ensembl1694,831,730 - 94,997,583 (-)Ensembl
RefSeq Acc Id: ENSMUST00000232562   ⟹   ENSMUSP00000156014
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1694,562,512 - 94,657,531 (-)Ensembl
GRCm38.p6 Ensembl1694,761,653 - 94,856,672 (-)Ensembl
RefSeq Acc Id: NM_001025584   ⟹   NP_001020755
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391694,549,542 - 94,798,555 (-)NCBI
GRCm381694,748,683 - 94,997,696 (-)ENTREZGENE
MGSCv371694,970,290 - 95,219,303 (-)RGD
Celera1695,836,338 - 96,085,607 (-)NCBI
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001025585   ⟹   NP_001020756
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391694,632,589 - 94,798,555 (-)NCBI
GRCm381694,831,730 - 94,997,696 (-)NCBI
MGSCv371694,970,290 - 95,219,303 (-)RGD
Celera1695,836,338 - 96,085,607 (-)NCBI
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001025590   ⟹   NP_001020761
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391694,623,391 - 94,657,549 (-)NCBI
GRCm381694,822,532 - 94,856,690 (-)NCBI
MGSCv371694,970,290 - 95,219,303 (-)RGD
Celera1695,836,338 - 96,085,607 (-)NCBI
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_010606   ⟹   NP_034736
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391694,561,939 - 94,798,555 (-)NCBI
GRCm381694,761,080 - 94,997,696 (-)NCBI
MGSCv371694,970,290 - 95,219,303 (-)RGD
Celera1695,836,338 - 96,085,607 (-)NCBI
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011246104   ⟹   XP_011244406
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391694,545,839 - 94,657,566 (-)NCBI
GRCm381694,744,980 - 94,856,707 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004939169
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391694,545,839 - 94,798,719 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001020755 (Get FASTA)   NCBI Sequence Viewer  
  NP_001020756 (Get FASTA)   NCBI Sequence Viewer  
  NP_001020761 (Get FASTA)   NCBI Sequence Viewer  
  NP_034736 (Get FASTA)   NCBI Sequence Viewer  
  XP_011244406 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA53245 (Get FASTA)   NCBI Sequence Viewer  
  AAA91457 (Get FASTA)   NCBI Sequence Viewer  
  AAC34141 (Get FASTA)   NCBI Sequence Viewer  
  AAC34142 (Get FASTA)   NCBI Sequence Viewer  
  AAC34143 (Get FASTA)   NCBI Sequence Viewer  
  AAC34144 (Get FASTA)   NCBI Sequence Viewer  
  AAC34145 (Get FASTA)   NCBI Sequence Viewer  
  AAC34284 (Get FASTA)   NCBI Sequence Viewer  
  AAC34285 (Get FASTA)   NCBI Sequence Viewer  
  AAC34286 (Get FASTA)   NCBI Sequence Viewer  
  AAC34287 (Get FASTA)   NCBI Sequence Viewer  
  AAI20795 (Get FASTA)   NCBI Sequence Viewer  
  AAI25566 (Get FASTA)   NCBI Sequence Viewer  
  BAA12972 (Get FASTA)   NCBI Sequence Viewer  
  BAA88430 (Get FASTA)   NCBI Sequence Viewer  
  BAC31823 (Get FASTA)   NCBI Sequence Viewer  
  BAC38135 (Get FASTA)   NCBI Sequence Viewer  
  BAE23876 (Get FASTA)   NCBI Sequence Viewer  
  EDL03718 (Get FASTA)   NCBI Sequence Viewer  
  EDL03719 (Get FASTA)   NCBI Sequence Viewer  
  EDL03720 (Get FASTA)   NCBI Sequence Viewer  
  EDL03721 (Get FASTA)   NCBI Sequence Viewer  
  EDL03722 (Get FASTA)   NCBI Sequence Viewer  
  EDL03723 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000093558
  ENSMUSP00000093558.5
  ENSMUSP00000097108
  ENSMUSP00000097108.3
  ENSMUSP00000130321
  ENSMUSP00000130321.2
  ENSMUSP00000156014
  ENSMUSP00000156014.2
GenBank Protein P48542 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001020755   ⟸   NM_001025584
- Peptide Label: isoform Girk2-1
- UniProtKB: Q8C4T8 (UniProtKB/TrEMBL),   Q3UTV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_034736   ⟸   NM_010606
- Peptide Label: isoform Girk2A-1
- UniProtKB: Q0VB45 (UniProtKB/TrEMBL),   Q3UTV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001020761   ⟸   NM_001025590
- Peptide Label: isoform Girk2C
- UniProtKB: A0A0R4J239 (UniProtKB/TrEMBL),   Q8C8Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001020756   ⟸   NM_001025585
- Peptide Label: isoform Girk2B
- UniProtKB: Q8C8Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011244406   ⟸   XM_011246104
- Peptide Label: isoform X1
- UniProtKB: A0A338P6L0 (UniProtKB/TrEMBL),   Q3UTV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000097108   ⟸   ENSMUST00000099508
RefSeq Acc Id: ENSMUSP00000130321   ⟸   ENSMUST00000165538
RefSeq Acc Id: ENSMUSP00000093558   ⟸   ENSMUST00000095873
RefSeq Acc Id: ENSMUSP00000156014   ⟸   ENSMUST00000232562
Protein Domains
Inward rectifier potassium channel C-terminal   Potassium channel inwardly rectifying transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48542-F1-model_v2 AlphaFold P48542 1-425 view protein structure

Promoters
RGD ID:13674534
Promoter ID:EPDNEW_M21416
Type:multiple initiation site
Name:Kcnj6_2
Description:Mus musculus potassium inwardly-rectifying channel, subfamilyJ, member 6 , transcript variant Girk2B, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M21417  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381694,856,696 - 94,856,756EPDNEW
RGD ID:13674536
Promoter ID:EPDNEW_M21417
Type:initiation region
Name:Kcnj6_1
Description:Mus musculus potassium inwardly-rectifying channel, subfamilyJ, member 6 , transcript variant Girk2B, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M21416  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381694,997,744 - 94,997,804EPDNEW
RGD ID:6827189
Promoter ID:MM_KWN:21822
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000056268
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361695,054,951 - 95,055,451 (-)MPROMDB
RGD ID:6827190
Promoter ID:MM_KWN:21824
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_001025584,   NM_001025585,   NM_010606,   UC008ABQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361695,219,131 - 95,219,631 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104781 AgrOrtholog
Ensembl Genes ENSMUSG00000043301 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000095873 ENTREZGENE
  ENSMUST00000095873.12 UniProtKB/TrEMBL
  ENSMUST00000099508 ENTREZGENE
  ENSMUST00000099508.4 UniProtKB/TrEMBL
  ENSMUST00000165538 ENTREZGENE
  ENSMUST00000165538.3 UniProtKB/TrEMBL
  ENSMUST00000232403 ENTREZGENE
  ENSMUST00000232562 ENTREZGENE
  ENSMUST00000232562.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1400 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir3.2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir_cyto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kir_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16522 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104781 ENTREZGENE
NCBI Gene 16522 ENTREZGENE
PANTHER PTHR11767 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11767:SF19 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IRK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB KCNJ6 RGD
PhenoGen Kcnj6 PhenoGen
PIRSF GIRK_kir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS KIR32CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KIRCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J239 ENTREZGENE, UniProtKB/TrEMBL
  A0A338P6L0 ENTREZGENE, UniProtKB/TrEMBL
  KCNJ6_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q0VB45 ENTREZGENE, UniProtKB/TrEMBL
  Q3UTV4 ENTREZGENE, UniProtKB/TrEMBL
  Q8C4T8 ENTREZGENE, UniProtKB/TrEMBL
  Q8C8Y6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O70290 UniProtKB/Swiss-Prot
  P70216 UniProtKB/Swiss-Prot
  P70306 UniProtKB/Swiss-Prot
  P70307 UniProtKB/Swiss-Prot
  P70308 UniProtKB/Swiss-Prot
  P70309 UniProtKB/Swiss-Prot
  P70454 UniProtKB/Swiss-Prot
  Q9QYH5 UniProtKB/Swiss-Prot