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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:53001
Term: nickel sulfate
Definition: A metal sulfate having nickel(2+) as the metal ion.
Chemical ID: MESH:C029938
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTDnickel sulfate results in increased expression of IL1B mRNAPMID:11114790
Il1bdecreases expressionISOIL1B (Homo sapiens)6480464CTDnickel sulfate results in decreased expression of IL1B mRNAPMID:29594315
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDnickel sulfate results in increased expression of IL1B mRNA; nickel sulfate results in increased expression of IL1B proteinPMID:11751209 PMID:16166746 PMID:25957741
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDnickel sulfate results in increased expression of IL1B mRNA; nickel sulfate results in increased expression of IL1B proteinPMID:16314067 PMID:16780908 PMID:19702435 PMID:20713136 PMID:21697260 PMID:25673294 PMID:30842373
Il1bincreases secretionISOIL1B (Homo sapiens)6480464CTDnickel sulfate results in increased secretion of IL1B proteinPMID:11033066 PMID:14650623
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTDQuercetin inhibits the reaction [nickel sulfate results in increased expression of IL1B protein]PMID:25957741
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTD[Tetradecanoylphorbol Acetate co-treated with nickel sulfate] results in increased expression of and results in increased secretion of IL1B protein; Zinc Sulfate inhibits the reaction [nickel sulfate results in increased secretion of IL1B protein]PMID:14650623 PMID:24964617
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