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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:31823
Term: mercury dichloride
Definition: A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID: MESH:D008627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTDMercuric Chloride results in increased expression of IL1B mRNAPMID:16507785 PMID:17250768
Il1bmultiple interactionsEXP 6480464CTDTretinoin inhibits the reaction [Mercuric Chloride results in increased expression of IL1B mRNA]PMID:17250768
Il1baffects expressionISOIl1b (Mus musculus)6480464CTDMercuric Chloride analog affects the expression of IL1B mRNAPMID:29981841
Il1baffects secretionISOIl1b (Mus musculus)6480464CTDMercuric Chloride affects the secretion of IL1B protein; Mercuric Chloride analog affects the secretion of IL1B proteinPMID:29981841
Il1bdecreases expressionISOIl1b (Mus musculus)6480464CTDMercuric Chloride results in decreased expression of IL1B proteinPMID:21984480
Il1bdecreases expressionISOIL1B (Homo sapiens)6480464CTDMercuric Chloride results in decreased expression of IL1B mRNAPMID:29594315
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDMercuric Chloride results in increased expression of IL1B mRNA; Mercuric Chloride results in increased expression of IL1B proteinPMID:25237059 PMID:29981841 PMID:37172713
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL1B mRNA; [Trichloroethylene co-treated with Mercuric Chloride] results in increased expression of IL1B mRNA; N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercuric Chloride results in increased expression of IL1B mRNA]PMID:21084432 PMID:25237059 PMID:28453771
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTDMercuric Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Mercuric Chloride inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Mercuric Chloride promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]PMID:20049214 PMID:21051542 PMID:9138684
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