GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il1b | increases expression | EXP | | 6480464 | CTD | deoxynivalenol results in increased expression of IL1B mRNA; deoxynivalenol results in increased expression of IL1B protein | PMID:32738333 PMID:34673182 | Il1b | multiple interactions | EXP | | 6480464 | CTD | GALP protein promotes the reaction [deoxynivalenol results in increased expression of IL1B protein] | PMID:32738333 | Il1b | decreases expression | ISO | IL1B (Homo sapiens) | 6480464 | CTD | deoxynivalenol results in decreased expression of IL1B mRNA | PMID:20702593 | Il1b | increases expression | ISO | Il1b (Mus musculus) | 6480464 | CTD | deoxynivalenol results in increased expression of IL1B mRNA; deoxynivalenol results in increased expression of IL1B protein | PMID:10344227 PMID:12604842 PMID:15371230 PMID:15681167 PMID:16009389 PMID:16687389 PMID:18433975 PMID:18614267 PMID:21873375 PMID:22454431 PMID:22968694 PMID:24793808 PMID:25392278 PMID:25549547 PMID:31034930 PMID:34400200 PMID:35381244 PMID:35817260 PMID:36309173 PMID:36602574 PMID:9194413 PMID:9707511 | Il1b | increases expression | ISO | IL1B (Homo sapiens) | 6480464 | CTD | deoxynivalenol results in increased expression of IL1B mRNA; deoxynivalenol results in increased expression of IL1B protein | PMID:16364386 PMID:33890134 | Il1b | increases secretion | ISO | Il1b (Mus musculus) | 6480464 | CTD | deoxynivalenol results in increased secretion of IL1B protein | PMID:35925383 PMID:36309173 | Il1b | increases secretion | ISO | IL1B (Homo sapiens) | 6480464 | CTD | deoxynivalenol results in increased secretion of IL1B protein | PMID:33170220 PMID:35925383 | Il1b | multiple interactions | ISO | Il1b (Mus musculus) | 6480464 | CTD | 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide promotes the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of IL1B mRNA]]; 6-formylindolo(3,2-b)carbazole inhibits the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of IL1B mRNA]]; [deoxynivalenol results in increased susceptibility to Antigens] which results in increased expression of IL1B protein; [Lipopolysaccharides co-treated with deoxynivalenol] results in increased expression of IL1B mRNA; [Lipopolysaccharides co-treated with deoxynivalenol] results in increased expression of IL1B protein; acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; BMAL1 protein inhibits the reaction [deoxynivalenol results in increased expression of IL1B protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; deoxynivalenol promotes the reaction [Antigens, Dermatophagoides results in increased expression of IL1B protein]; deoxynivalenol promotes the reaction [fumonisin B1 results in increased expression of IL1B mRNA]; deoxynivalenol promotes the reaction [fumonisin B1 results in increased expression of IL1B protein]; deoxynivalenol promotes the reaction [fumonisin B1 results in increased secretion of IL1B protein]; deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; fumonisin B1 promotes the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; fumonisin B1 promotes the reaction [deoxynivalenol results in increased expression of IL1B protein]; fumonisin B1 promotes the reaction [deoxynivalenol results in increased secretion of IL1B protein]; HMOX1 protein inhibits the reaction [deoxynivalenol results in increased expression of IL1B protein]; Lipopolysaccharides promotes the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; Lipopolysaccharides promotes the reaction [deoxynivalenol results in increased expression of IL1B protein]; Poly I-C promotes the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; resiquimod promotes the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; stattic inhibits the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; Zymosan promotes the reaction [deoxynivalenol results in increased expression of IL1B mRNA] | PMID:12773775 PMID:16009389 PMID:16687389 PMID:22454431 PMID:28935500 PMID:31034930 PMID:33170220 PMID:35381244 PMID:35817260 PMID:35925383 PMID:36309173 PMID:36602574 | Il1b | multiple interactions | ISO | IL1B (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; [GSDME protein co-treated with deoxynivalenol] results in increased secretion of IL1B protein; [Zearalenone co-treated with deoxynivalenol] results in increased expression of IL1B mRNA; Adenine inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [deoxynivalenol results in increased secretion of IL1B protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [deoxynivalenol results in increased secretion of IL1B protein]; deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased abundance of Nitric Oxide]; deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]; deoxynivalenol inhibits the reaction [IL1B protein results in increased expression of CXCL8 protein]; deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; lactacystin inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; pyrrolidine dithiocarbamic acid inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; SB 203580 inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]] | PMID:16687389 PMID:18308354 PMID:25766886 PMID:35090964 PMID:35925383 | | ||||||||||||||||||||||
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