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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:31823
Term: mercury dichloride
Definition: A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID: MESH:D008627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5affects expressionEXP 6480464CTDMercuric Chloride affects the expression of HSPA5 mRNAPMID:15111246
Hspa5increases expressionEXP 6480464CTDMercuric Chloride results in increased expression of HSPA5 mRNA; Mercuric Chloride results in increased expression of HSPA5 proteinPMID:17915553 PMID:30807803
Hspa5multiple interactionsEXP 6480464CTDCycloheximide inhibits the reaction [Mercuric Chloride results in increased expression of HSPA5 protein]; Dactinomycin inhibits the reaction [Mercuric Chloride results in increased expression of HSPA5 mRNA]; Mercuric Chloride promotes the reaction [HSPA5 protein binds to FOS enhancer]; Mercuric Chloride promotes the reaction [HSPA5 protein binds to HRAS enhancer]; Mercuric Chloride results in increased expression of and results in increased activity of HSPA5 proteinPMID:15111246 PMID:17915553
Hspa5increases expressionISOHspa5 (Mus musculus)6480464CTDMercuric Chloride results in increased expression of HSPA5 proteinPMID:32879258
Hspa5multiple interactionsISOHspa5 (Mus musculus)6480464CTD4-phenylbutyric acid inhibits the reaction [Mercuric Chloride results in increased expression of HSPA5 protein]PMID:32879258
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