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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5decreases expressionISOHspa5 (Mus musculus)6480464CTDdeoxynivalenol results in decreased expression of HSPA5 mRNAPMID:10652249
Hspa5decreases expressionISOHSPA5 (Homo sapiens)6480464CTDdeoxynivalenol results in decreased expression of HSPA5 mRNAPMID:20682335 PMID:24356939
Hspa5increases phosphorylationISOHspa5 (Mus musculus)6480464CTDdeoxynivalenol results in increased phosphorylation of HSPA5 proteinPMID:23811945
Hspa5multiple interactionsISOHspa5 (Mus musculus)6480464CTDcalpain inhibitor III inhibits the reaction [deoxynivalenol results in increased degradation of HSPA5 protein]; deoxynivalenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPA5 mRNA]; deoxynivalenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPA5 protein]; deoxynivalenol results in increased degradation of and results in decreased expression of HSPA5 protein; phenylalanyl-glycyl-NHO-Bz inhibits the reaction [deoxynivalenol results in increased degradation of HSPA5 protein]PMID:10652249 PMID:19336499
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