GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hmox1 | decreases abundance | EXP | | 6480464 | CTD | HMOX1 protein results in decreased abundance of Heme | PMID:16959961 | Hmox1 | increases degradation | EXP | | 6480464 | CTD | HMOX1 protein results in increased degradation of Heme | PMID:20638379 | Hmox1 | multiple interactions | EXP | | 6480464 | CTD | [stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Heme; Heme promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of HMOX1 protein] | PMID:16959961 PMID:17292349 | Hmox1 | decreases abundance | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | HMOX1 protein results in decreased abundance of Heme | PMID:18178725 | Hmox1 | decreases expression | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | Heme results in decreased expression of HMOX1 mRNA | PMID:9224953 | Hmox1 | increases degradation | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | HMOX1 protein results in increased degradation of Heme | PMID:19136476 | Hmox1 | increases expression | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | Heme metabolite results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 mRNA | PMID:19191707 PMID:7538129 PMID:8630002 | Hmox1 | increases expression | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | Heme analog results in increased expression of HMOX1 protein; Heme results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 protein | PMID:10874044 PMID:12783778 PMID:15242350 PMID:17156779 PMID:19952508 PMID:32671443 | Hmox1 | increases metabolic processing | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | HMOX1 protein results in increased metabolism of Heme | PMID:22859313 | Hmox1 | multiple interactions | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | [Heme binds to HPX protein] which results in increased expression of HMOX1 protein; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; HMOX1 enhancer affects the reaction [Heme results in increased expression of HMOX1 mRNA]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]] | PMID:19039664 PMID:7538129 | Hmox1 | multiple interactions | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | [HMOX1 protein results in increased degradation of Heme] which results in increased abundance of Iron; NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]; SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA] | PMID:10874044 PMID:17156779 PMID:19136476 | | ||||||||||||||||||||||
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