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GENE - TERM ANNOTATION REPORT

RGD ID: 2688
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ghrhr
Name: growth hormone releasing hormone receptor
Acc ID: GO:0007189
Term: adenylate cyclase-activating G protein-coupled receptor signaling pathway
Definition: A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling.
Definition Source(s): GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ghrhracts_upstream_of_or_withinISOGhrhr (Mus musculus)1624291RGDMGI:1856425 MGI:95709 PMID:10537133 PMID:1334535 PMID:3008329 PMID:8391647 PMID:8395283

PMID:10537133 PMID:1334535 PMID:3008329 PMID:8391647 PMID:8395283
Ghrhrinvolved_inISOGHRHR (Homo sapiens)1624291RGD PMID:1333056 PMID:7680413

PMID:1333056 PMID:7680413
Ghrhrinvolved_inIEAUniProtKB:P32082 or ensembl:ENSMUSP000000681201600115EnsemblGO_REF:0000107

GO_REF:0000107
Ghrhrinvolved_inIEAUniProtKB:Q02643 or ensembl:ENSP000003201801600115EnsemblGO_REF:0000107

GO_REF:0000107
Ghrhrinvolved_inIBAMGI:95710 or PANTHER:PTN002898380 or UniProtKB:Q026431600115GO_CentralGO_REF:0000033

GO_REF:0000033
Ghrhrinvolved_inIEAPANTHER:PTHR45620:SF141600115TreeGrafterGO_REF:0000118

GO_REF:0000118
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