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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2654
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gadd45a
Name: growth arrest and DNA-damage-inducible, alpha
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gadd45aaffects response to substanceISOGADD45A (Homo sapiens)6480464CTDGADD45A affects the susceptibility to FluorouracilPMID:15067352
Gadd45aaffects response to substanceISOGadd45a (Mus musculus)6480464CTDGADD45A protein affects the susceptibility to FluorouracilPMID:16732331
Gadd45adecreases expressionISOGadd45a (Mus musculus)6480464CTDFluorouracil results in decreased expression of GADD45A mRNAPMID:19272435
Gadd45aincreases expressionISOGADD45A (Homo sapiens)6480464CTDFluorouracil results in increased expression of GADD45A mRNA; Fluorouracil results in increased expression of GADD45A proteinPMID:15205334 PMID:16709241 PMID:17982676 PMID:19003803 PMID:19098008 PMID:22525470 PMID:30177839
Gadd45aincreases response to substanceISOGADD45A (Homo sapiens)6480464CTDGADD45A protein results in increased susceptibility to FluorouracilPMID:19003803
Gadd45amultiple interactionsISOGADD45A (Homo sapiens)6480464CTDTP53 protein affects the reaction [Fluorouracil results in increased expression of GADD45A mRNA]; TP53 protein promotes the reaction [Fluorouracil results in increased expression of GADD45A mRNA]PMID:15016801 PMID:17982676
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