GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Erbb2 | decreases phosphorylation | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | gefitinib results in decreased phosphorylation of ERBB2 protein | PMID:16243822 | Erbb2 | multiple interactions | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of ERBB2 protein]; gefitinib results in decreased activity of [EGFR protein binds to ERBB2 protein] | PMID:17898861 | |
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