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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:16978
Term: leukotriene C4
Definition: A leukotriene that is (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid in which a glutathionyl group is attached at position 6 via a sulfide linkage.
Chemical ID: MESH:D017997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1increases expressionISOEDN1 (Homo sapiens)6480464CTDLeukotriene C4 results in increased expression of EDN1 mRNA; Leukotriene C4 results in increased expression of EDN1 proteinPMID:11372388
Edn1multiple interactionsISOEDN1 (Homo sapiens)6480464CTDzafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 mRNA]; zafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 protein]PMID:11372388
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