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GENE - TERM ANNOTATION REPORT

RGD ID: 2493
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ace
Name: angiotensin I converting enzyme
Acc ID: DOID:10652
Term: Alzheimer's disease
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Alzheimer%27s_disease "DO" "DO", http://www.merriam-webster.com/medical/alzheimer%27s%20disease "DO" "DO", http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ace IMP 2325232RGD  
Ace ISOACE (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:9916793 PMID:10643899 PMID:14872014 PMID:17192785 PMID:30820047
Ace ISOACE (Homo sapiens)1331525GAD  
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