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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp7a1multiple interactionsEXP 6480464CTD[Chenodeoxycholic Acid co-treated with Ketoconazole] results in decreased expression of CYP7A1 mRNAPMID:30985903
Cyp7a1increases expressionISOCyp7a1 (Mus musculus)6480464CTDKetoconazole results in increased expression of CYP7A1 mRNAPMID:31099283
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