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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2396
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cpt1a
Name: carnitine palmitoyltransferase 1A
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cpt1adecreases expressionISOCPT1A (Homo sapiens)6480464CTDPaclitaxel results in decreased expression of CPT1A proteinPMID:30667213
Cpt1amultiple interactionsISOCPT1A (Homo sapiens)6480464CTD[Paclitaxel co-treated with FV-429 compound co-treated with Oxygen deficiency] results in increased expression of CPT1A mRNAPMID:34648812
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