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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Comt
Name: catechol-O-methyltransferase
Acc ID: CHEBI:35298
Term: anthracene
Definition: An ortho-fused tricyclic hydrocarbon comprising three fused benzene rings.
Chemical ID: MESH:C034020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Comtmultiple interactionsISOCOMT (Homo sapiens)6480464CTD[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT proteinPMID:28710019
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