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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2359
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Grem1
Name: gremlin 1, DAN family BMP antagonist
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grem1decreases expressionISOGREM1 (Homo sapiens)6480464CTDTretinoin results in decreased expression of GREM1 mRNAPMID:21934132
Grem1decreases expressionISOGrem1 (Mus musculus)6480464CTDTretinoin results in decreased expression of GREM1 mRNAPMID:36189433
Grem1multiple interactionsISOGrem1 (Mus musculus)6480464CTD[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of GREM1 mRNAPMID:36189433
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