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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cftr
Name: CF transmembrane conductance regulator
Acc ID: CHEBI:34457
Term: 5-Nitro-2-(3-phenylpropylamino)benzoic acid
Definition: A nitrobenzoic acid that has formula C16H16N2O4.
Chemical ID: MESH:C058176
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cftrdecreases activityEXP 6480464CTD5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CFTR proteinPMID:15389550
Cftrdecreases activityISOCFTR (Homo sapiens)6480464CTD5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CFTR proteinPMID:15131065 PMID:15277574 PMID:15634668 PMID:15802612 PMID:15857825
Cftrmultiple interactionsISOCFTR (Homo sapiens)6480464CTD5-nitro-2-(3-phenylpropylamino)benzoic acid analog binds to and results in increased activity of CFTR protein; 5-nitro-2-(3-phenylpropylamino)benzoic acid analog binds to and results in increased activity of CFTR protein mutant form; 5-nitro-2-(3-phenylpropylamino)benzoic acid binds to and results in increased activity of CFTR protein; 5-nitro-2-(3-phenylpropylamino)benzoic acid binds to and results in increased activity of CFTR protein mutant formPMID:15857825
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