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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2293
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd3
Name: cyclin D3
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd3affects response to substanceISOCCND3 (Homo sapiens)6480464CTDCCND3 affects the susceptibility to Fluorouracil; CCND3 protein affects the susceptibility to FluorouracilPMID:15067352 PMID:15548681 PMID:18383818
Ccnd3increases expressionISOCCND3 (Homo sapiens)6480464CTDFluorouracil results in increased expression of CCND3 mRNAPMID:16709241
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