Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2279
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Cat
Name:	catalase

Acc ID:	CHEBI:79068
Term:	crocin-1
Definition:	A diester that is crocetin in which both of the carboxy groups have been converted to their gentiobiosyl esters. It is one of the water-soluble yellow-red pigments of saffron and is used as a spice for flavouring and colouring food. Note that in India, the term 'Crocin' is also used by GlaxoSmithKline as a brand-name for paracetamol.
Chemical ID:	MESH:C029036

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Cat	increases activity	EXP		6480464	CTD	crocin results in increased activity of CAT protein	PMID:25899501
Cat	multiple interactions	EXP		6480464	CTD	crocin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; crocin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; crocin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]	PMID:25899501 PMID:29409856 PMID:32920515
Cat	decreases activity	ISO	CAT (Homo sapiens)	6480464	CTD	crocin results in decreased activity of CAT protein	PMID:32886819
Cat	multiple interactions	ISO	Cat (Mus musculus)	6480464	CTD	crocin inhibits the reaction [Patulin results in increased activity of CAT protein]; crocin inhibits the reaction [Zearalenone results in increased activity of CAT protein]	PMID:26231423 PMID:26584762

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