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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2254
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Calca
Name: calcitonin-related polypeptide alpha
Acc ID: CHEBI:6456
Term: lidocaine
Definition: The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Chemical ID: MESH:D008012
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Calcaincreases expressionEXP 6480464CTDLidocaine results in increased expression of CALCA mRNAPMID:35283115
Calcamultiple interactionsEXP 6480464CTDLidocaine inhibits the reaction [Potassium results in increased secretion of CALCA protein]PMID:18178321
Calcaincreases secretionISOCalca (Mus musculus)6480464CTDLidocaine results in increased secretion of CALCA proteinPMID:18172555
Calcamultiple interactionsISOCalca (Mus musculus)6480464CTDcapsazepine inhibits the reaction [Lidocaine results in increased secretion of CALCA protein]; TRPV1 protein affects the reaction [Lidocaine results in increased secretion of CALCA protein]PMID:18172555
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