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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2070
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agtr1a
Name: angiotensin II receptor, type 1a
Acc ID: CHEBI:5959
Term: irbesartan
Definition: A biphenylyltetrazole that is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.
Chemical ID: MESH:C081309
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtr1aaffects response to substanceISOAGTR1 (Homo sapiens)6480464CTDAGTR1 gene polymorphism affects the susceptibility to irbesartanPMID:11910301
Agtr1amultiple interactionsISOAGTR1 (Homo sapiens)6480464CTDirbesartan binds to and results in decreased activity of AGTR1 proteinPMID:12022239
Agtr1amultiple interactionsISOAgtr1a (Mus musculus)6480464CTDCholesterol inhibits the reaction [irbesartan results in increased expression of AGTR1 mRNA]PMID:19028402
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