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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2056
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adra2a
Name: adrenoceptor alpha 2A
Acc ID: CHEBI:8364
Term: prazosin
Definition: A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Chemical ID: MESH:D011224
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adra2amultiple interactionsEXP 6480464CTDPrazosin binds to and results in decreased activity of ADRA2A proteinPMID:8397342
Adra2amultiple interactionsISOADRA2A (Homo sapiens)6480464CTDPrazosin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]]PMID:10742289
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