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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2056
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adra2a
Name: adrenoceptor alpha 2A
Acc ID: CHEBI:7824
Term: oxcarbazepine
Definition: A dibenzoazepine derivative, having a carbamoyl group at the ring nitrogen, substituted with an oxo group at C-4 of the azepeine ring which is also hydrogenated at C-4 and C-5. It is a anticholinergic anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy.
Chemical ID: MESH:C036006
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adra2amultiple interactionsEXP 6480464CTD[BRL 44408 binds to and results in decreased activity of ADRA2A protein] which results in decreased susceptibility to oxcarbazepinePMID:17959985
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